Introduction: Over the past three decades, the field of kidney transplantation in Saudi Arabia has witnessed significant growth, innovation, and diversity in organ sources. Living related donor transplants have steadily increased, and living unrelated donor transplants were introduced in 2010. This study aimed to assess the progress and resilience of the transplantation field in overcoming global challenges, such as the COVID-19 pandemic, and adapting to changing circumstances.

Methods: A retrospective analysis of kidney transplantation data from various transplant centers across Saudi Arabia was conducted, focusing on living and deceased donor transplants. The total number of kidney transplants, along with the distribution of living related, living unrelated, and deceased donor transplants, were analyzed to evaluate the growth and success of kidney transplantation in the country.

Results: In 2022, living related donor transplants reached their highest numbers, showcasing the progress and resilience of the transplantation field. King Faisal Specialist Hospital (KFSH) in Riyadh emerged as a leading kidney transplant center, performing 432 kidney transplants, including 363 living related, 16 living unrelated, and 53 deceased donor transplants. In total, transplant centers performed over 1,160 kidney transplants.

Conclusion: The narrative of kidney transplantation in Saudi Arabia demonstrates the dedication of healthcare professionals and the positive impact of these procedures on countless individuals and families. Despite the slight decline in deceased donor transplants due to the COVID-19 pandemic, living donor transplants remained stable, reflecting the resilience of the transplantation field. Continued focus on innovation and adaptation to global challenges will be crucial in further advancing kidney transplantation outcomes in Saudi Arabia.