Renal transplant is the best solution for treatment patients with chronic renal failure. Five year survival of patients after kidney transplant is 85% comparing to hemodialysis 35%. The first kidney transplant from living donor was done in 1954 by Dr. Joseph Murray and Dr.David Hume in Boston at Brigham Hospital, in 1962 the same team performed kidney transplant from deceased donor.

Limited number of donors is common and persistent problem with organ donation. Many areas of organ donation are focused on popularisation of organ donation, however lack of Donors is also connected with contraindications for organ donating such as agening of donors, arteriosclerosis, organ insufficiency, current or recent malignancy and risk of transmission . 

Different group of tumors is prostate cancer, second most common cancerous tumor worldwide, occur more frequent with age. Different biology of this cancer is followed with the most heritable of all major neoplasm, around 59 % of prostate malignancy is driven by genetic factors, hormone dependent and anatomy of prostate. These factors give opportunity for conservative treatment of this cancer and also permit opportunity to qualify donors with that kind of disease. 

In our Department of General Surgery and Transplantation twenty four kidneys were transplanted from donors with diagnosed prostate Cancer during last five years.  We have not observed malignancy transmission from donor to recipient during follow up, with no abnormalities checked with radiology and laboratory tests.    

Donors with prosthetic cancer which have different biology comparing to other malignancies should not be disqualified, however further research on large number of donors and other organs should be continued.